Research

 

Stem Cell Therapy Research

The Center for Wellbeing provides a research-backed approach to healing. We use the most advanced regenerative therapies to reduce pain and increase relief through healing the root cause of chronic conditions.

Here are some of the latest and relevant academic and medical studies in regenerative medicine, stem cell therapy and restorative approaches. This is a highly advanced field and we are more than happy to discuss and encourage you to ask our team questions in your consultation.

Wharton’s Jelly-Derived Mesenchymal Stem Cells: Phenotypic Characterization and Optimizing Their Therapeutic Potential for Clinical Applications

Wharton’s jelly (WJ) is a gelatinous tissue within the umbilical cord that contains myofibroblast-like stromal cells. A unique cell population of WJ that has been suggested as displaying the stemness phenotype is the mesenchymal stromal cells (MSCs)….

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Knee Cartilage Regeneration with Umbilical Cord Mesenchymal Stem Cells Embedded in Collagen Scaffold Using Dry Arthroscopy Technique

Mesenchymal stem cells (MSC) provide an interesting new option in regenerative medicine with solid preclinical data and first promising clinical results…

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Wharton’s Jelly The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells. (MSC)

The umbilical cord has become an increasingly used source of mesenchymal stromal cells for preclinical and, more recently, clinical studies. Despite the increased activity, several aspects of this cell population have been under-appreciated…

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Umbilical Cord Tissue for Research and Clinical Application

Variations in allogeneic mesenchymal stem cell harvest levels from human tissues reflect the evolving nature of the field, patient demographic characteristics, and differences in harvest and isolation techniques. At present,Wharton’s jelly tissue yields the highest concentration of allogeneic mesenchymal stem cells…

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Effect of Aging on Stem Cells

Pluripotent stem cells have the remarkable self-renewal ability and are capable of differentiating into multiple diverse cells. There is increasing evidence that the aging process can have adverse effects on stem cells. As stem cells age, their renewal ability deteriorates and their ability to differentiate into the various cell types is altered…

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Mesenchymal Stem Cells: Mechanisms of Inflammation

In adults, human mesenchymal stem cells (hMSCs) are found in vivo at low frequency and are defined by their capacity to differentiate into bone, cartilage, and adipose tissue, depending on the stimuli and culture conditions under which they are expanded…

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Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative Medicine

The amniotic membrane (AM) and amniotic fluid (AF) have a long history of use in surgical and prenatal diagnostic applications, respectively…

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Minimal criteria for defining multipotent mesenchymal stromal cells.

The considerable therapeutic potential of human multipotent mesenchymal stromal cells (MSC) has generated markedly increasing interest in a wide variety of biomedical disciplines…

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Intramuscular administration potentiates extended dwell time of mesenchymal stromal cells compared to other routes

Mesenchymal stromal cells (MSCs) offer great potential for diverse clinical applications. However, conventional systemic infusion of MSCs limits their therapeutic benefit, since intravenously (IV) infused cells become entrapped in the lungs where their dwell time is short…

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Cytotoxicity of Local Anesthetics on Human Mesenchymal Stem Cells

Local anesthetics are frequently delivered intra-articularly to provide perioperative pain control. Previous studies have shown that the commonly used drugs lidocaine, ropivacaine, and bupivacaine can be toxic to human chondrocytes…

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Mesenchymal stem cells and immunomodulation: current status and future prospects

The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders…

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Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect

Intravenous (IV) stem cell delivery for regenerative tissue therapy has been increasingly used in both experimental and clinical trials. However, recent data suggest that the majority of administered stem cells are initially trapped in the lungs. We sought to investigate variables that may affect this pulmonary first-pass effect…

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Multipotent Stem Cells from Umbilical Cord: Cord Is Richer than Blood!

The identification of mesenchymal stem cell (MSC) sources that are easily obtainable is of utmost importance. Several studies have shown that MSCs could be isolated from umbilical cord (UC) units…

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The life and fate of mesenchymal stem cells

Mesenchymal stem cells (MSC) are present throughout the body and are thought to play a role in tissue regeneration and control of inflammation…

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Umbilical cord mesenchymal stromal cell transplantations: A systemic analysis of clinical trials

The advances and success of umbilical cord–derived mesenchymal stromal cells (UC-MSCs) in experimental disease animal models have fueled the development of targeted therapies in humans…

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Mesenchymal Stem Cells as Trophic Mediators

Adult marrow-derived Mesenchymal Stem Cells (MSCs) are capable of dividing and their progeny are further capable of differentiating into one of several mesenchymal phenotypes such as osteoblasts, chondrocytes, myocytes, marrow stromal cells, tendon-ligament fibroblasts, and adipocytes…

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Mesenchymal stem cells for cartilage repair in osteoarthritis

Osteoarthritis (OA) is a degenerative disease of the connective tissue and progresses with age in the older population or develops in young athletes following sports-related injury. The articular cartilage is ….

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Restoration of a large osteochondral defect of the knee using a composite of umbilical cord-derived mesenchymal stem cells and hyaluronic acid hydrogel: a case report with a 5-year follow-up

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Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy

There are limited options for tissue restoration and the prevention of degenerative changes in the knee. Stem cells have ….

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Mesenchymal stem cell therapy for knee osteoarthritis: 5 years follow-up of three patients

Osteoarthritis (OA) is a biomechanical disease progressing gradually to the degradation of joint cartilage. Knee OA is one of the most frequent forms of osteoarthritis. It has a high prevalence in Asian countries ….

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Platelet Rich Plasma

Platelet Rich Plasma: a short overview of certain bioactive components

Platelet rich plasma (PRP) represents a relatively new approach in regenerative medicine. It is obtained from patient’s own blood and contains different growth factors and other biomolecules necessary for wound healing….

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