Research

 

Stem Cell Therapy Research

The Center for Wellbeing provides a research-backed approach to healing. We use the most advanced regenerative therapies to reduce pain and increase relief through healing the root cause of chronic conditions.

Here are some of the latest academic and medical studies in regenerative medicine, stem cell therapy and restorative approaches. We are more than happy to discuss any questions you may have in your consultation.

Wharton’s Jelly-Derived Mesenchymal Stem Cells: Phenotypic Characterization and Optimizing Their Therapeutic Potential for Clinical Applications

Wharton’s jelly (WJ) is a gelatinous tissue within the umbilical cord that contains myofibroblast-like stromal cells. A unique cell population of WJ that has been suggested as displaying the stemness phenotype is the mesenchymal stromal cells (MSCs)….

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Wharton’s Jelly The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells. (MSC)

The umbilical cord has become an increasingly used source of mesenchymal stromal cells for preclinical and, more recently, clinical studies. Despite the increased activity, several aspects of this cell population have been under-appreciated…

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Umbilical Cord Tissue for Research and Clinical Application

Variations in allogeneic mesenchymal stem cell harvest levels from human tissues reflect the evolving nature of the field, patient demographic characteristics, and differences in harvest and isolation techniques. At present,Wharton’s jelly tissue yields the highest concentration of allogeneic mesenchymal stem cells…

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Effect of Aging on Stem Cells

Pluripotent stem cells have the remarkable self-renewal ability and are capable of differentiating into multiple diverse cells. There is increasing evidence that the aging process can have adverse effects on stem cells. As stem cells age, their renewal ability deteriorates and their ability to differentiate into the various cell types is altered…

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Consequences of Telomere Shortening During Lifespan

Telomerase expression is restricted in human cells and so telomeres shorten throughout our lives, providing a tumor suppressor mechanism that limits cell proliferation. As a trade-off, continuous telomere erosion results in replicative senescence and contributes to aging…

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Mesenchymal Stem Cells: Mechanisms of Inflammation

In adults, human mesenchymal stem cells (hMSCs) are found in vivo at low frequency and are defined by their capacity to differentiate into bone, cartilage, and adipose tissue, depending on the stimuli and culture conditions under which they are expanded…

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Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative Medicine

The amniotic membrane (AM) and amniotic fluid (AF) have a long history of use in surgical and prenatal diagnostic applications, respectively…

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Minimal criteria for defining multipotent mesenchymal stromal cells.

The considerable therapeutic potential of human multipotent mesenchymal stromal cells (MSC) has generated markedly increasing interest in a wide variety of biomedical disciplines…

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Cytokines, Inflammation and Pain

Cytokines are small secreted proteins released by cells have a specific effect on the interactions and communications between cells…

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Intramuscular administration potentiates extended dwell time of mesenchymal stromal cells compared to other routes

Mesenchymal stromal cells (MSCs) offer great potential for diverse clinical applications. However, conventional systemic infusion of MSCs limits their therapeutic benefit, since intravenously (IV) infused cells become entrapped in the lungs where their dwell time is short…

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Cytotoxicity of Local Anesthetics on Human Mesenchymal Stem Cells

Local anesthetics are frequently delivered intra-articularly to provide perioperative pain control. Previous studies have shown that the commonly used drugs lidocaine, ropivacaine, and bupivacaine can be toxic to human chondrocytes…

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Mesenchymal stem cells and immunomodulation: current status and future prospects

The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders…

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Knee Cartilage Regeneration with Umbilical Cord Mesenchymal Stem Cells Embedded in Collagen Scaffold Using Dry Arthroscopy Technique

Mesenchymal stem cells (MSC) provide an interesting new option in regenerative medicine with solid preclinical data and first promising clinical results…

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Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect

Intravenous (IV) stem cell delivery for regenerative tissue therapy has been increasingly used in both experimental and clinical trials. However, recent data suggest that the majority of administered stem cells are initially trapped in the lungs. We sought to investigate variables that may affect this pulmonary first-pass effect…

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Multipotent Stem Cells from Umbilical Cord: Cord Is Richer than Blood!

The identification of mesenchymal stem cell (MSC) sources that are easily obtainable is of utmost importance. Several studies have shown that MSCs could be isolated from umbilical cord (UC) units…

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Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial

Despite advances in early diagnosis and behavioral therapies, more effective treatments for children with autism spectrum disorder (ASD) are needed…

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The life and fate of mesenchymal stem cells

Mesenchymal stem cells (MSC) are present throughout the body and are thought to play a role in tissue regeneration and control of inflammation…

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Potency of umbilical cord blood and Wharton’s jelly-derived mesenchymal stem cells for scarless wound healing

Postnatally, scars occur as a consequence of cutaneous wound healing. Scarless wound healing is highly desired for patients who have undergone surgery or trauma, especially to exposed areas…

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Umbilical cord mesenchymal stromal cell transplantations: A systemic analysis of clinical trials

The advances and success of umbilical cord–derived mesenchymal stromal cells (UC-MSCs) in experimental disease animal models have fueled the development of targeted therapies in humans…

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Inflammation and wound healing: The role of the macrophage

The macrophage is a prominent inflammatory cell in wounds, but its role in healing remains incompletely understood. Macrophages have been described to have many functions in wounds, including host defense, the promotion and resolution of inflammation, the removal of apoptotic cells, and the support of cell proliferation and tissue restoration following injury…

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Mesenchymal Stem Cells as Trophic Mediators

Adult marrow-derived Mesenchymal Stem Cells (MSCs) are capable of dividing and their progeny are further capable of differentiating into one of several mesenchymal phenotypes such as osteoblasts, chondrocytes, myocytes, marrow stromal cells, tendon-ligament fibroblasts, and adipocytes…

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Mesenchymal stem cells for cartilage repair in osteoarthritis

Osteoarthritis (OA) is a degenerative disease of the connective tissue and progresses with age in the older population or develops in young athletes following sports-related injury. The articular cartilage is ….

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Restoration of a large osteochondral defect of the knee using a composite of umbilical cord-derived mesenchymal stem cells and hyaluronic acid hydrogel: a case report with a 5-year follow-up

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Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy

There are limited options for tissue restoration and the prevention of degenerative changes in the knee. Stem cells have ….

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Mesenchymal stem cell therapy for knee osteoarthritis: 5 years follow-up of three patients

Osteoarthritis (OA) is a biomechanical disease progressing gradually to the degradation of joint cartilage. Knee OA is one of the most frequent forms of osteoarthritis. It has a high prevalence in Asian countries ….

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Platelet Rich Plasma

Platelet Rich Plasma: a short overview of certain bioactive components

Platelet rich plasma (PRP) represents a relatively new approach in regenerative medicine. It is obtained from patient’s own blood and contains different growth factors and other biomolecules necessary for wound healing….

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ED Therapy Research

Low-intensity shock wave therapy in men with erectile dysfunction and Peyronie’s disease: An analysis of predictors of clinical success and patient satisfaction rate based on prospective open-label single arm clinical trial.

This study evaluates factors that predict clinical success and patient satisfaction rate among men with ED and/or PD following LiESWT…

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Is there a role for extracorporeal shock wave therapy for erectile dysfunction unresponsive to phosphodiesterase type 5 inhibitors?

We read with great interest the invited review by Fojecki and colleagues regarding the role of extracorporeal shock wave therapy (ESWT) in urology…

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Low-Intensity Extracorporeal Shock Wave Therapy in Vascular Disease and Erectile Dysfunction: Theory and Outcomes

Low-intensity extracorporeal shock wave therapy (LI-ESWT) to the penis has recently emerged as a new and promising modality in the treatment of erectile dysfunction (ED)…

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Can low-intensity extracorporeal shockwave
therapy improve erectile dysfunction? A prospective, randomized, double-blind, placebo-controlled study

Recent studies have shown promising results of low-intensity extracorporeal shockwave therapy (LI-ESWT) on patients suffering from mild to severe erectile dysfunction…

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Safety and efficacy of low intensity shockwave (LISW) treatment in patients with erectile dysfunction.

The primary goal in the management strategy of a patient with ED would be to determine its etiology and cure it when possible, and not just to treat the symptoms alone. One of the new therapeutic strategies is the use of low intensity extracorporeal shockwave (LISW) therapy…

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Low-Intensity Shock Wave Therapy and Its Application to Erectile Dysfunction

Although phosphodiesterase type 5 inhibitors (PDE5Is) are a revolution in the treatment of erectile dysfunction (ED) and have been marketed since 1998, they cannot restore pathological changes in the penis…

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Con: does shockwave therapy have a place in the treatment of Peyronie’s disease?

Extracorporeal Shockwave Therapy (ESWT) has been used to treat various urological conditions such as nephrolithiasis and erectile dysfunction. The use of ESWT for Peyronie’s disease (PD) has been a subject of debate since Bellorofobate et al. published the first report on the use of ESWT on a PD patient in 1989…

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Pro: does shockwave therapy have a place in the treatment of Peyronie’s disease?

Peyronie’s disease (PD) is an often debilitating psychosexual condition characterized by the presence of penile pain, deformity and plaque(s), with ensuing erectile dysfunction…

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Shockwave treatment of erectile dysfunction

Low-intensity extracorporeal shock wave therapy (LI-ESWT) is a novel modality that has recently been developed for treating erectile dysfunction (ED). Unlike other current treatment options for ED, all of which are palliative in nature, LI-ESWT is unique in that it aims to restore the erectile mechanism in order to enable natural or spontaneous erections…

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Twelve-Month Efficacy and Safety of Low-Intensity Shockwave Therapy for Erectile Dysfunction in Patients Who Do Not Respond to Phosphodiesterase Type 5 Inhibitors

Erectile dysfunction (ED) is a medical entity that is highly prevalent in men older than 50 years whose history of vascular risk factors (VRFs) has been a common denominator in the origin of this symptom…

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Peyronie’s disease and low intensity shock wave therapy: Clinical outcomes and patient satisfaction rate in an open-label single arm prospective study in Australian men

Purpose: To evaluate the efficacy, safety and patient satisfaction outcomes following low intensity extracorporeal shock wave therapy (LiESWT) in men with Peyronie’s disease (PD) using a standardised protocol…

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Penile Low-Intensity Shock Wave Therapy: A Promising Novel Modality for Erectile Dysfunction

Penile extracorporeal low-intensity shock wave therapy (LIST) to the penis has recently emerged as a novel and promising modality in the treatment of erectile dysfunction
(ED)…

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Shockwave Therapy as First-Line Treatment for Peyronie’s Disease: A Prospective Study

To assess in a prospective study whether shockwave therapy (SWT) is effective as a first-line treatment for Peyronie’s disease…

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Treatment of Peyronie’s Disease by Extracorporeal Shockwave Therapy: Evaluation of Our Preliminary Results

Peyronie’s disease is an idiopathic disorder of the penis that produces erectile dysfunction. It affects
mainly the tunica albugínea. We describe our preliminary results with extracorporal Shockwave therapy
(ESWT) as a new noninvasive modality for the treatment of Peyronie’s disease…

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Extracorporeal shockwave therapy in the treatment of erectile dysfunction: A prospective, randomized, double-blinded, placebo controlled study

To investigate the role of low-intensity extracorporeal shockwave therapy in the treatment of erectile dysfunction…

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Safety and efficacy of low intensity shockwave (LISW) treatment in patients with erectile dysfunction

The primary goal in the management strategy of a patient with ED would be to determine its etiology and cure it when possible, and not just to treat the symptoms alone. One of the new therapeutic strategies…

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Peyronie’s diseaseÐthe Plymouth experience of extracorporeal shockwave treatment

Results Of the 28 patients, 20 felt that their erection improved after the procedure; 11 patients were able to recommence sexual intercourse and the index of erectile function increased in all but one patient…

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Evaluation of clinical efficacy, safety and patient satisfaction rate after low-intensity extracorporeal shockwave therapy for the treatment of male erectile dysfunction: an Australian first open-label single-arm prospective clinical trial

Erectile dysfunction (ED) is a common psychosexual condition affecting men across all ages and the current management strategies consist of a step-wise approach with modification of risk factors, optimisation of existing medical comorbidities followed by medical therapy…

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Therapeutic advances in the treatment of Peyronie’s disease

Peyronie’s disease (PD) is an under-diagnosed condition with prevalence in the male population as high as 9%. It is a localized connective tissue disorder of the penis characterized by scarring of the tunica albuginea. Its pathophysiology, however, remains incompletely elucidated…

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Does Low Intensity Extracorporeal Shock Wave Therapy Have a Physiological Effect on Erectile Function? Short-Term Results of a Randomized, Double-Blind, Sham Controlled Study

Clinically we found a significantly greater increase in the International Index of Erectile Function-Erectile Function domain score from visit 1 to followup 1 in the treated group…

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Penile Low Intensity Shock Wave Treatment is Able to Shift PDE5i Nonresponders to Responders: A Double-Blind,
Sham Controlled Study

In the low intensity shock wave treatment group and the sham group 54.1% and 0% of patients, respectively…

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Low-Intensity Extracorporeal Shock Wave Therapy—A Novel Effective Treatment for Erectile Dysfunction in Severe ED Patients
Who Respond Poorly to PDE5 Inhibitor Therapy

Introduction. Low-intensity shock wave therapy (LI-ESWT) has been reported as an effective treatment in men with mild and moderate erectile dysfunction (ED)…

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Impact of aging and comorbidity on the efficacy of low-intensity shock wave therapy for erectile dysfunction

Objectives: To evaluate the efficacy of low-intensity shock wave therapy and to identify the predictive factors of its efficacy in Japanese patients with erectile dysfunction…

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Initial experience with linear focused shockwave treatment for erectile dysfunction: a 6-month follow-up pilot study

Low-intensity shockwaves (LISW) are known to produce revascularization and have been in evaluation and in use to treat erectile dysfunction (ED). The present single-arm pilot study…

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Tadalafil once daily and extracorporeal shock wave therapy in the management of patients with Peyronie’s disease and erectile dysfunction: results from a prospective randomized trial

Extracorporeal shock wave therapy improves erectile function in patients with Peyronie’s disease. However, erectile dysfunction still persists in many cases. We aimed to investigate the effects…

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Can Low-Intensity Extracorporeal Shockwave Therapy Improve
Erectile Function? A 6-Month Follow-up Pilot Study in Patients
with Organic Erectile Dysfunction

Background: Low-intensity extracorporeal shockwave therapy (LI-ESWT) is currently
under investigation regarding its ability to promote neovascularization in different
organs…

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Our Experience on the Association of a New Physical and Medical Therapy in Patients Suffering from Induratio penis plastica

At the present time, Peyronie’s disease is still an unknown disorder and both the pathophysiology and therapeutic approach of this disease are not well established…

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Low-intensity Extracorporeal Shock Wave Treatment Improves Erectile Function: A Systematic Review and Meta-analysis

Phosphodiesterase type 5 inhibitors (PDE5-Is) are currently
the most widely used treatments for male erectile dysfunction
(ED); however, these medications merely treat ED symptoms.
They do not correct the underlying penile pathophysiology…

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Low intensity extracorporeal shockwave therapy for erectile dysfunction: a study in an Indian population

Low intensity extracorporeal shockwave therapy for erectile dysfunction: a study in an Indian population…

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Efficiency Assessment of Shock Wave Therapy in Patients with Pelvic Pain Employing Harmonic Analysis of Penile Bioimpedance

In searching for novel objective methods to diagnosticate pelvic pain and assess efficiency of
analgesic therapy, 37 male patients were examined prior to and after the course of extracorporeal
shockwave therapy…

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Men’s Power-Shock Wave Erectile Regeneration Therapy:
an Early Assessment

Introduction: Low intensity extracorporeal shockwave therapy for erectile dysfunction (LISWT) has been well researched as a treatment for Erectile Dysfunction (ED) and used as a first line treatment…

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Testimonials

"After years of osteoarthritis in my knees I am virtually pain-free.”
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" I am so thrilled because I cancelled my knee replacement surgery after having the regenerative stem cell exosome therapy. I am 100 percent better than I was." 
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